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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Single-cell transcriptomics in ovarian cancer identify a metastasis-associated cell cluster overexpressed RAB13

Fig. 7

RAB13 promotes cell migration via regulating the tight junction and actin cytoskeleton. RAB13 inhibits the phosphorylation of VASP and suppress the binding of TJP1 with claudin and occludin by suppressing the ability of PKA, leading to decreased cell adhesion; Meanwhile, RAB13 forms a complex with JRAB and inhibits the remodeling of cytoskeleton by affecting filamin, thereby promoting the migration ability of cancer cells

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Journal of Translational Medicine

ISSN: 1479-5876

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