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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Phase separation in cancer at a glance

Fig. 3

An innovative PROTAC, ARV-825, which links BRD4 to E3 ubiquitin ligase, effectively degrades BRD4 protein. ARV-825-induced BRD4 aggregation disrupts LLPS and suppresses BRD-4-dependent transcription. PROTAC proteolysis targeting chimera

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