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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Rocuronium bromide suppresses esophageal cancer via blocking the secretion of C–X–C motif chemokine ligand 12 from cancer associated fibroblasts

Fig. 5

Activation of autophagy in fibroblasts induced by RB. A The activities of PI3K/AKT/mTOR, and the expression of LC3II/I, ATG5 and CXCL12 in human fibroblasts HS-27, TIG-1 and CRL-7815 induced by RB using WB assay. B The statistical analysis of the phosphorylated kinases of WB assay. C The statistical analysis of the expression of LC3II/I, ATG5 and CXCL12. D The expression of ATG5 and CXCL12 in CAFs of xenograft mice in vivo using IHC assay. Images are shown with 100 magnification. E The statistical analysis of ATG5 and CXCL12 of IHC assay. F Graphical overview of this study. RB plays a tumor suppressive role in EC through governing the CXCL12 secretion from CAFs. Data are presented as the mean ± standard error, n ≥ 3. *, #P < 0.05, **, ##P < 0.01, ***, ###P < 0.001 compared with each control

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Journal of Translational Medicine

ISSN: 1479-5876

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