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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model

Fig. 6

DG interneuron hyperactivity persists in late-stage AD and coincides with increased inhibition of dentate GCs. A Representative fiber photometry calcium activity traces of MS (magenta) and DG (green) GABA neurons in 14 months old Vgat-WT and Vgat-AD mice during home-cage recording. B Quantification of cumulative activity of DG interneurons in 14 months old Vgat-WT and Vgat-AD mice during home cage recordings. n = 6, 8 mice, p < 0.05. C Quantification of cumulative activity of MS GABA neurons in 14 month Vgat-WT and Vgat-AD mice during home cage recording. n = 6, 8 mice. D Cumulative distribution of sIPSC interval in GCs of Vgat-WT and Vgat-AD mice, p = 0.462. E Mean frequency of GC sIPSCs in Vgat-WT and Vgat-AD. p = 0.59, n = 8, 9 cells. F Cumulative distribution of sIPSC amplitude in GCs of Vgat-WT and Vgat-AD mice during acute slice electrophysiology, p < 0.0001. G Mean amplitude of GC sIPSCs in Vgat-WT and Vgat-AD mice. p = 0.01, n = 8, 9 cells. H Action potential distribution with various current steps in GCs of Vgat-WT and Vgat-AD mice. Two-way ANOVA, p = 0.003. I Quantification of GC input resistance in 14 month Vgat-WT and Vgat-AD mice. p = 0.009, n = 9, 9 cells

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