Skip to main content
Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model

Fig. 5

Activation of MS-DG GABAergic projections alters the inhibitory inputs onto GCs during early-stage AD. A Schematic of viral injection of ChR2 and blue light stimulation of septo-DG circuit projections to the hilus. B Representative traces of GC sIPSCs before, during (blue frame), and after blue light stimulation. C Quantification of sIPSC frequency in GCs before and during light stimulation in Vgat-WT mice, n = 5 cells. D Quantification of sIPSC frequency in GCs before and during light stimulation in Vgat-AD mice, n = 8 cells. E Quantification of sIPSC amplitude in GCs before and during light stimulation in Vgat-WT mice, n = 5 cells. F Quantification of sIPSC amplitude in GCs before and during light stimulation in Vgat-AD mice, n = 8 cells. *p < 0.05 by paired t-test. Error bars indicate SEM

Back to article page