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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model

Fig. 3

DG interneurons exhibit hyperactivity during early-stage AD. A Scheme of AAV injection and optical fiber implantation in the DG and MS of 6 month Vgat-WT and Vgat-AD mice. B Representative calcium activity traces of DG (green) and MS (magenta) GABAergic neurons in Vgat-WT and Vgat-AD mice during home cage recording. The dotted lines indicated the 3 SD thresholds. C Quantification of calcium activity in DG interneurons during home cage recordings in Vgat-WT and Vgat-AD mice. p < 0.05, n = 7, 5 mice. D Quantification of calcium activity in MS GABA during home cage recordings in Vgat-WT and Vgat-AD mice. n.s., n = 7, 5 mice. E Cumulative distribution of GC sIPSC amplitude in Vgat-WT and Vgat-AD mice. F Mean amplitude of GC sIPSCs in Vgat-WT and Vgat-AD. p = 0.065, n = 8, 12 cells. G Cumulative distribution of GC sIPSC interval in Vgat-WT and Vgat-AD mice. H Mean frequency of GC sIPSCs in Vgat-WT and Vgat-AD. p = 0.43, n = 8, 11 cells

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