Skip to main content
Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model

Fig. 2

Activities of MS and DG GABAergic neurons correlate during spatial memory encoding. A VGAT-Cre animals with dual injection of AAV5-DIO-GCaMP6f and optical fiber implantation to the DG and MS. Enlarged implantation region schematics in the DG (i) and MS (ii). 4 Vgat-WT mice were included in analysis. B Representative images of GCaMP6f expression in the DG (i, scale bar = 200 μm) and MS (ii, scale bar = 100 μm). C Diagram of Vgat-Cre animals trained and tested in the NPR. D Time spent in exploring object-A and object-B during familiarization and test phase in the NPR test. n = 4 mice, paired t-test, *p < 0.05. E Scaled heat maps of DG and MS GABA neuron activity distribution when approaching objects A and B during the familiarization phase of the NPR test. F Averaged calcium activity of DG (green, left) and MS (magenta, right) GABA neuron activity pre, during, and post exploration of objects A and B during the familiarization phase of the NPR test. G Pearson correlation analysis of MS and DG GABA neuron calcium activity during interactions with objects A and B during the familiarization phase of the NPR test. Data points represent time-locked exploration events during NPR trials. H Scaled heat maps of DG and MS GABA neuron activity distribution when approaching objects A and B during the retrieval phase of the NPR test. I Averaged calcium activity of DG (green, left) and MS (magenta, right) GABA neuron activity pre, during, and post exploration of objects A and B during the test phase of the NPR trial. J Pearson correlation analysis of MS and DG interneuron calcium activity during interactions with objects A and B during the retrieval phase of the NPR test. Data points represent time-locked exploration events during NPR trials

Back to article page