Table 1 Clinical characteristics of the 15 patients with GCLM
Characteristics | Number of patients | Percentage of patients (%) |
|---|---|---|
Median age, years (range) | 60 (30–75) | |
Sex | Â | Â |
 Female | 1 | 6.7 |
 Male | 14 | 93.3 |
Disease stage at diagnosis | Â | Â |
 III | 5 | 33.3 |
 IV | 10 | 66.7 |
Site of primary gastric cancer | Â | Â |
 Cardia | 5 | 33.3 |
 Corpus | 7 | 46.7 |
 Antrum | 3 | 20.0 |
Metastasis sites prior to leptomeningeal |  |  |
 Liver | 1 | 6.7 |
 Lung | 2 | 13.3 |
 Bone | 3 | 20.0 |
 Lymph nodes | 8 | 53.3 |
 Brain | 1 | 6.7 |
 None | 4 | 26.7 |
Treatment prior to CNS metastasis |  |  |
 Naive | 4 | 26.7 |
 Chemotherapy | 4 | 26.7 |
 Chemotherapy combined with other therapies | 7 | 46.7 |
Treatment after CNS metastasis |  |  |
 Naive | 1 | 6.7 |
 Chemotherapy | 12 | 80.0 |
 Chemotherapy combined with other therapies | 2 | 13.3 |
Neurological symptoms of CNS |  |  |
 Headache | 14 | 93.3 |
 Nausea, vomiting | 13 | 86.7 |
 Dizzy | 7 | 46.7 |
 Vision loss | 6 | 40.0 |
 Hearing loss | 4 | 26.7 |
 Muscular weakness | 4 | 26.7 |
 Lalopathy | 3 | 20.0 |
 Ataxia | 2 | 13.3 |
 Osphyalgia | 2 | 13.3 |
 Neck pain | 2 | 13.3 |