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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Genomic alterations of cerebrospinal fluid cell-free DNA in leptomeningeal metastases of gastric cancer

Fig. 5

The dynamic change of driver genes in CSF ctDNA throughout therapy in a GCLM case. A The treatment history, serial genetic profile from the tumor, plasma, and CSF samples, imaging results, and cytology data of a male GCLM patient. Time point a (CSF 1) represents the time of initial diagnosis on Oct 25, 2016, time point b (CSF 2) represents the time of disease remission on Dec 29, 2016, time point c represents the time of diagnosing peritoneal metastasis on July 28, 2017, and CSF 4 was collected at disease recurrence on Oct 5, 2017. B The dynamic change of allele frequency of various mutations detected in serial CSF samples collected during the course of treatment

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