Fig. 3

Gene Ontology (GO) analysis of the differentially expressed EV-miRNA target genes. GO enrichment of biological processes (A) and molecular functions (B) of EV-miRNA target genes in OW/OB vs NW breast cancer patients. DAVID database was used for GO-term functional annotation analysis. Data showed the top 15 significant GO terms with FDR (false discovery rate) values of < 0.05 and a p-value of < 0.05. C. Protein–protein interaction (PPI) analysis of the deregulated EV-miRNA target genes constructed using the Search Tool for the Retrieval of Interacting Gene (STRING; https://string-db.org/) database. Each node indicates a protein module; the edges represent protein interactions. Different color indicates different type of interactions. (Cyan-from curated databases; Pink-experimentally determined; Khaki- text mining). PPIs with a p < 0.05 were considered statistically significant