Fig. 3

Systemic inflammation across periodontal health conditions during exposure to MetS factors follows a sex-specific pattern. Panel A Stratified analysis of serum CRP levels across periodontal health conditions based on exposure. Panel B Sex-stratified analysis of serum CRP levels of exposed and non-exposed across periodontal health conditions. Panel C Sex-stratified analysis of serum CRP levels by presence and extent of gingival bleeding. Panel D Sex-stratified analysis of serum CRP levels by incremental MetS components. Panel E Sex-stratified analysis of PISA by incremental MetS components. Panel F Sex-specific correlation of PISA and CRP levels based on exposure. Panel G Heatmap of CRP levels on individuals with single MetS components across periodontal health conditions. Asterisk indicates significant different mean CRP levels compared to healthy controls. Wilcoxon test adjusted for multiple comparisons with Bonferroni correction. Ns: not significant; *p < 0.05; **p < 0.01; p < 0.001; p < 0.0001