Fig. 2
The coexpression module of serum exosome metabolites is dysregulated in remote ischemic preconditioning (RIPC) participants. A Dendrogram of metabolite coexpression modules; B Log2 (fold change) distribution of metabolites in the blue, brown, green, red, turquoise, and yellow modules; C Pearson’s correlation coefficient between S0-S38 and module eigengene. S0: Group; S1: Visual selection reaction time (plain); S2: Blood oxygen saturation (SpO2) (4500 m); S3: Auditory simple reaction time (plain); S4: Nation; S5: Diastolic pressure (mmHg) (4500 m); S6: Blood oxygen saturation (SpO2) (plain); S7: Lake Louise Acute Mountain Sickness Scoring System (Gastrointestinal symptoms); S8: Digital decoding (4500 m); S9: Spatial memory (number of passes; 4500 m); S10: Digital decoding (plain); S11: Pulse (plain); S12: Systolic pressure (mmHg) (plain); S13: Target tracking (correct average dot; 4500 m); S14: Pulse (4500 m); S15: Auditory simple reaction time (4500 m); S16: Systolic pressure (mmHg) (4500 m); S17: Left prefrontal cerebral oxygen rSO2% (plain); S18: Weight; S19: Left prefrontal cerebral oxygen rSO2% (4500 m); S20: Height; S21: Diastolic pressure (mmHg) (plain); S22: Manual dexterity (dominant hand; 4500 m); S23: Right frontal cerebral oxygen saturation rSO2% (4500 m); S24: Target tracking (correct average dot; plain); S25: Target tracking (total average dot; plain); S26: Manual dexterity (non-dominant hand; 4500 m); S27: Spatial memory (number of passes; plain); S28: Spatial memory (plain); S29: Target tracking (total average dot; 4500 m); S30: Manual dexterity (non-dominant hand; plain); S31: Visual selection reaction time (4500 m); S32: Lake Louise Acute Mountain Sickness Scoring System (Dizziness); S33: Lake Louise Acute Mountain Sickness Scoring System (Headache); S34: Spatial memory (4500 m); S35: Right frontal cerebral oxygen saturation rSO2% (plain); S36: Lake Louise Acute Mountain Sickness Scoring System (Fatigue and/or weakness); S37: Manual dexterity (dominant hand; plain); S38: Lake Louise Acute Mountain Sickness Scoring System (Total scores)