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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Tumor-targeted superantigens produce curative tumor immunity with induction of memory and demonstrated antigen spreading

Fig. 7

C215Fab-SEA induced increased frequencies of Ag-specific memory T cells. A, B Heatmaps displaying the mean log2-fold expression values of selected genes of T-cell costimulatory and coinhibitory receptors (A-up) and genes associated with T-cell exhaustion and memory development (B-left) in tumors upon different treatments over the treatment cycles (C1–C3). The color gradient indicates the fold increase relative to the matched control. The right (A) or bottom B heatmaps show the p values of the significant differences in the up (A) or left (B) heatmaps, respectively. White represents a nonsignificant expression change compared to the matched control. Differential expression analysis was performed with Welch’s t test. n = 3–4/group/timepoint. C Violin plots showing the percentage of CD127-expressing cells among total non-Vβ3 CD8 + T cells in the TDLNs (left graphs) and tumors (right graphs). D Violin plots showing the percentage of CD39-expressing cells among the total non-Vβ3 CD8+ T cells in the TDLNs (left graphs) and tumors (right graphs). The timepoints in all figures are indicated as C1-C4 (cycles 1–4, respectively). n = 3–4/group/timepoint. Statistical significance was determined by two-way ANOVA with Tukey’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, versus the timepoint-matched control, for C4 Combo versus C215Fab-SEA

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