Fig. 6

Systemic administration of M1-polarized CAR-Ms resulted in a potent antitumor response in a melanoma lung metastasis model. A An illustration of the experimental design. B Representative gross images of lungs excised from the indicated treatment groups at the experimental endpoint. C Quantitative analysis of metastatic foci from (B). Data are shown as the mean ± SEM. D Antitumoural efficacy was assessed by the lung weight-to-body weight ratio of mice bearing intravenous B16F10-HER2 cells posttreatment. E Lung metastatic burden assessed by HE staining. *, p < 0.05; **, p < 0.01; ***, p < 0.001