Fig. 4

Local administration of polarized CAR-Ms suppressed the progression of ovarian cancer in vivo. A Schematic illustration of the experimental design for the ovarian cancer model. B The appearance of ascites/peritoneal lavage obtained from tumor-bearing mice after intraperitoneal administration. C Kaplan‒Meier survival curve of tumor-bearing mice treated with GFP-M, GFP-M1, CAR-M, and CAR-M1 after ID8-HER2 tumor cell inoculation. D Tumor burden assessed by body weight after the mice received GFP-M, GFP-M1, CAR-M, and CAR-M1 treatment. E Statistical analysis of bioluminescence imaging. Data are presented as the mean ± S.D. F Tumor burden was monitored by bioluminescence imaging on the indicated days after treatment. *, p < 0.05; **, p < 0.01; ***, p < 0.001