Fig. 2
From: Role of OAS gene family in COVID-19 induced heart failure
Data processing and hub genes screening in GSE120852. A Volcano plot of DEGs from GSE120852. X-axis indicates log2(FC) and the Y-axis indicates − log10(P-value). Red and green dots represent upregulated and downregulated DEGs, respectively. Grey dots represent genes not differentially expressed. Result of diff1 and diff3 came from left ventricle (LV) tissue, results of diff2 and diff4 were from right ventricle (RV) tissue, diff1 and diff2 are the results of comparing the left ventricle heart failure (LV-HF) and non-failing (NF) heart. Diff3 and diff4 are the results of comparing the biventricular heart failure (Bi-HF) and NF hearts. B Heatmap displaying all genes identified from GSE120852, with each column representing sample and each row indicating gene. RV-NF: right ventricular tissue, non-failing heart; LV-NF: LV tissue from non-failing hearts; RV-HF: failing right ventricular tissue; RV-Bi-HF: right ventricle tissue from biventricular failing hearts; LV-HF: failing LV tissue; LV-Bi-HF: left ventricular tissue from biventricular heart failure. C Venn diagram of DEGs in GSE120862. There were 239 common different genes in diff1- 4, 169 were up-expressed and 70 were down-expressed. D OAS gene family expression in GSE120862. E PPI network of common DEGs shown with dots. Yellow dots represent hub genes showing in F. F Top 30 hub genes calculated by cytohubba. Of these genes, OAS1, OAS2, OAS3, and OASL ranked 15, 6, 2, and 6, respectively