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Table 1 Patient’s characteristics: mutational analysis of overall sample

From: The Glioma-IRE project − Molecular profiling in patients with glioma: steps toward an individualized diagnostic and therapeutic approach

Characteristics

n = 99, n (%)

Gender

• Male

65 (66)

• Female

34 (34)

• Age at diagnosis (years), median (min–max)

57 (19–81)

• Median (min–max)

57 (19–81)

Histology

• GBM

66 (67)

• Other glioma

33 (33)

MGMT (missing)

• Methylated

39 (42)

• Not methylated

53 (58)

Type of tissue

• Diagnosis

73 (74)

• Relapse

26 (26)

Previous treatments (CT and or RT)

• Yes

25 (25)

• No

73 (75)

Clinical response at NGS panel determination (7 not evaluable)

• CR/PR/NED

13 (14)

• SD

15 (16)

• PD

65 (70)

OS status (at 35 months)

• Alive

45 (45)

• Dead

54 (55)

  1. CR complete response, CT chemotherapy, GBM glioblastoma multiforme, MGMT O6-methylguanine DNA methyl-transferase, NED no evidence of disease, NGS next-generation sequencing, OS overall survival, PD progressive disease, PR partial response, RT radiotherapy, SD stable disease