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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: LncRNA H19-rich extracellular vesicles derived from gastric cancer stem cells facilitate tumorigenicity and metastasis via mediating intratumor communication network

Fig. 7

H19 delivered by CSCs-EVs activates the YAP/CDX2 signaling axis and facilitates the tumorigenicity and metastasis of NSCCs in vivo. A H19 and CDX2 expression in tumor tissues of mice treated with CSCs-EVs or CSCs-EVs-sh-H19 analyzed by RT-qPCR. B Positive expression of CDX2 and active YAP proteins in tumor tissues of mice treated with CSCs-EVs or CSCs-EVs-sh-H19 detected by immunohistochemistry. C Tumor weight of mice treated with CSCs-EVs or CSCs-EVs-sh-H19. D, Representative images of liver tissues and the quantitative analysis of liver metastases in mice treated with CSCs-EVs or CSCs-EVs-sh-H19. E, H&E staining of tumor tissues and liver tissues of mice treated with CSCs-EVs or CSCs-EVs-sh-H19. *p < 0.05. n = 8 mice for each treatment

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