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Table 2 Key regulated factor of the MMP family in HNSC

From: Identification of the MMP family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma

Key TF

Description

Regulated gene

P value

FDR

JUN

jun proto-oncogene

MMP1, MMP2, MMP3, MMP7, MMP9, MMP12, MMP13, MMP20

8.23e−12

1.97e−10

STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

MMP1, MMP2, MMP3, MMP7, MMP9, MMP10, MMP14

3.65e−10

4.38e−09

ETV4

ets variant 4

MMP1, MMP2, MMP7, MMP14

1.45e−08

1.16e−07

ETS1

v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)

MMP1, MMP3, MMP9, MMP10, MMP13

4.51e−08

2.71e−07

RELA

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

MMP1, MMP2, MMP3, MMP9, MMP12, MMP13, MMP14

6.7e−08

2.82e−07

ETS2

v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

MMP1, MMP2, MMP3, MMP9

7.06e−08

2.82e−07

MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

MMP1, MMP9, MMP14

1.01e−07

3.46e−07

FOS

FBJ murine osteosarcoma viral oncogene homolog

MMP1, MMP3, MMP7, MMP9

7.59e−07

2.28e−06

NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

MMP1, MMP2, MMP3, MMP9, MMP13, MMP14

1.72e−06

4.15e−06

NFKBIA

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

MMP1, MMP3, MMP9

1.73e−06

4.15e−06

SRF

serum response factor (c-fos serum response element-binding transcription factor)

MMP2, MMP9, MMP14

4.08e−06

8.9e−06

NCOA3

Nuclear receptor coactivator 3

MMP7, MMP10

3.24e−05

6.49e−05

KLF8

Kruppel-like factor 8

MMP9,MMP14

4.32e−05

7.98e−05

SNAI2

snail homolog 2 (Drosophila)

MMP9, MMP17

1.40e−04

2.40e−04

SP1

Sp1 transcription factor

MMP2, MMP9, MMP11, MMP14, MMP28

2.75e−04

4.12e−04

RUNX2

runt-related transcription factor 2

MMP2, MMP13

2.62e−04

4.12e−04

CTNNB1

catenin (cadherin-associated protein), beta 1, 88 kDa

MMP7, MMP14

3.53e−04

4.98e−04

YBX1

Y box binding protein 12

MMP2, MMP13

6.60e−04

8.8e−04

TWIST1

twist basic helix-loop-helix transcription factor 1

MMP1, MMP2

8.99e−04

0.001

PPARG

peroxisome proliferator-activated receptor gamma

MMP1, MMP9

0.003

0.004

HDAC1

histone deacetylase 1

MMP9, MMP28

0.004

0.004

TFAP2A

transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2

MMP2, MMP9

0.004

0.004

STAT1

signal transducer and activator of transcription 1, 91 kDa

MMP9, MMP13

0.005

0.005

TP53

tumor protein p53

MMP1, MMP2

0.018

0.018