Key TF | Description | Regulated gene | P value | FDR |
---|---|---|---|---|
JUN | jun proto-oncogene | MMP1, MMP2, MMP3, MMP7, MMP9, MMP12, MMP13, MMP20 | 8.23e−12 | 1.97e−10 |
STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | MMP1, MMP2, MMP3, MMP7, MMP9, MMP10, MMP14 | 3.65e−10 | 4.38e−09 |
ETV4 | ets variant 4 | MMP1, MMP2, MMP7, MMP14 | 1.45e−08 | 1.16e−07 |
ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | MMP1, MMP3, MMP9, MMP10, MMP13 | 4.51e−08 | 2.71e−07 |
RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | MMP1, MMP2, MMP3, MMP9, MMP12, MMP13, MMP14 | 6.7e−08 | 2.82e−07 |
ETS2 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) | MMP1, MMP2, MMP3, MMP9 | 7.06e−08 | 2.82e−07 |
MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | MMP1, MMP9, MMP14 | 1.01e−07 | 3.46e−07 |
FOS | FBJ murine osteosarcoma viral oncogene homolog | MMP1, MMP3, MMP7, MMP9 | 7.59e−07 | 2.28e−06 |
NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | MMP1, MMP2, MMP3, MMP9, MMP13, MMP14 | 1.72e−06 | 4.15e−06 |
NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | MMP1, MMP3, MMP9 | 1.73e−06 | 4.15e−06 |
SRF | serum response factor (c-fos serum response element-binding transcription factor) | MMP2, MMP9, MMP14 | 4.08e−06 | 8.9e−06 |
NCOA3 | Nuclear receptor coactivator 3 | MMP7, MMP10 | 3.24e−05 | 6.49e−05 |
KLF8 | Kruppel-like factor 8 | MMP9,MMP14 | 4.32e−05 | 7.98e−05 |
SNAI2 | snail homolog 2 (Drosophila) | MMP9, MMP17 | 1.40e−04 | 2.40e−04 |
SP1 | Sp1 transcription factor | MMP2, MMP9, MMP11, MMP14, MMP28 | 2.75e−04 | 4.12e−04 |
RUNX2 | runt-related transcription factor 2 | MMP2, MMP13 | 2.62e−04 | 4.12e−04 |
CTNNB1 | catenin (cadherin-associated protein), beta 1, 88 kDa | MMP7, MMP14 | 3.53e−04 | 4.98e−04 |
YBX1 | Y box binding protein 12 | MMP2, MMP13 | 6.60e−04 | 8.8e−04 |
TWIST1 | twist basic helix-loop-helix transcription factor 1 | MMP1, MMP2 | 8.99e−04 | 0.001 |
PPARG | peroxisome proliferator-activated receptor gamma | MMP1, MMP9 | 0.003 | 0.004 |
HDAC1 | histone deacetylase 1 | MMP9, MMP28 | 0.004 | 0.004 |
TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2 | MMP2, MMP9 | 0.004 | 0.004 |
STAT1 | signal transducer and activator of transcription 1, 91Â kDa | MMP9, MMP13 | 0.005 | 0.005 |
TP53 | tumor protein p53 | MMP1, MMP2 | 0.018 | 0.018 |