Grpel2 maintains cardiomyocyte survival in diabetic cardiomyopathy through DLST-mediated mitochondrial dysfunction: a proof-of-concept study

Table 1 Pressure–volume loop data

	Con + AAV9-Ctrl n = 6	Con + AAV9-Grpel2 n = 6	DCM + AAV9-Ctrl n = 6	DCM + AAV9-Grpel2 n = 6
ESPVR, mmHg/ml	23.46 ± 2.39	22.19 ± 2.45	15.54 ± 1.39*	18.79 ± 2.04^#
EDPVR, mmHg/ml	0.041 ± 0.005	0.054 ± 0.006	0.156 ± 0.004*	0.106 ± 0.003^#
Tau, ms	7.76 ± 0.29	8.19 ± 0. 54	10.78 ± 1.09*	9.49 ± 1.01^#
+ dP/dt, mmHg/s	5930 ± 131	5971 ± 143	2569 ± 214*	3742 ± 325^#
− dP/dt, mmHg/s	3562 ± 176	3687 ± 217	2196 ± 235*	2957 ± 167^#
LVESP, mmHg	128.56 ± 11.71	130.33 ± 9.81	85.33 ± 8.59*	104.17 ± 6.24^#
LVEDP, mmHg	4.67 ± 0.83	5.35 ± 1.07	12.12 ± 1.06*	7.48 ± 1.15^#

Data are mean ± SD
ESPVR, end systolic pressure–volume relationship; EDPVR, end diastolic pressure–volume relationship; LV, left ventricle; ESP, end-systolic pressure; EDP, end-diastolic pressure
*p < 0.05 versus Con + AAV9-Ctrl, ^#p < 0.05 versus DCM + AAV9-Ctrl, using one-way ANOVA, followed by Tukey’s post-hoc test

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