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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Grpel2 maintains cardiomyocyte survival in diabetic cardiomyopathy through DLST-mediated mitochondrial dysfunction: a proof-of-concept study

Fig. 2

Overexpression of cardiac Grpel2 alleviated heart remodeling in DCM. A, B Representative images of haematoxylin and eosin (HE) staining of cardiac sections (n = 6/group). Scale bar = 2 mm. B Quantification of the heart weight/tibia length (HW/TL) ratio (n = 6/group). C Representative images of wheat germ agglutinin (WGA) staining (top) and Masson trichrome staining (bottom) of cardiac sections. Scale bars: 25 μm (top) and 50 μm (bottom). D, E Quantitative analysis of the cross-sectional area of cardiomyocytes (D) and number of cardiomyocytes (E) by WGA staining. F Quantitative analysis of interstitial fibrosis by Masson trichrome staining (n = 6/group). G, H Quantitative real-time PCR (qRT-PCR) of the mRNA levels of hypertrophy-associated genes (G) and fibrosis-associated genes (H) in the left ventricle of mice (n = 6/group). I, J Representative images and quantitative analysis of TUNEL staining of cardiac sections (n = 6/group). Scale bar: 50 μm. K Quantification of relative caspase 3 activity in the left ventricle of mice (n = 6/group). Data are presented as the mean ± SD. Data were analysed by one-way ANOVA, followed by Tukey’s post hoc test. *p < 0.05

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