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Table 6 Mediation analysis for BMI and NAFLD via lipid parameters in the whole population stratified by sex

From: Lipid metabolism, BMI and the risk of nonalcoholic fatty liver disease in the general population: evidence from a mediation analysis

Mediator

Total effect

Mediation effect

Direct effect

PM (%)

P-value of PM

Men (n = 7441)

     

 TC

0.110 (0.088, 0.132)

0.001 (0.000, 0.002)

0.109 (0.087, 0.131)

1

0.006

 TG

0.110 (0.087, 0.132)

0.005 (0.001, 0.008)

0.105 (0.083, 0.128)

4.4

< 0.001

 HDL-C

0.111 (0.088, 0.133)

0.004 (0.002, 0.007)

0.106 (0.084, 0.128)

3.9

< 0.001

 LDL-C

0.110 (0.088, 0.132)

0.002 (0.001, 0.003)

0.108 (0.086, 0.131)

1.7

< 0.001

 Non-HDL-C

0.110 (0.087, 0.132)

0.004 (0.002, 0.006)

0.107 (0.084, 0.129)

3.2

< 0.001

 RC

0.110 (0.087, 0.132)

0.007 (0.003, 0.010)

0.104 (0.081, 0.126)

5.9

< 0.001

 TC/HDL-C ratio

0.111 (0.088, 0.133)

0.008 (0.005, 0.011)

0.103 (0.080, 0.125)

7

< 0.001

 TG/HDL-C ratio

0.111 (0.088, 0.132)

0.006 (0.003, 0.010)

0.105 (0.082, 0.127)

5.5

< 0.001

 LDL/HDL-C ratio

0.111 (0.088, 0.132)

0.007 (0.004, 0.009)

0.104 (0.082, 0.127)

5.9

< 0.001

 Non-HDL-C/HDL-C ratio

0.111 (0.088, 0.133)

0.008 (0.005, 0.011)

0.103 (0.080, 0.125)

7

< 0.001

 RC/HDL-C ratio

0.111 (0.088, 0.132)

0.008 (0.005, 0.012)

0.102 (0.080, 0.125)

7

< 0.001

Women (n = 6840)

     

 TC

0.084 (0.073, 0.097)

0.001 (0.000, 0.002)

0.083 (0.072, 0.096)

1

0.046

 TG

0.084 (0.073, 0.096)

0.010 (0.008, 0.012)

0.074 (0.063, 0.087)

11.7

< 0.001

 HDL-C

0.084 (0.073, 0.097)

0.005 (0.003, 0.006)

0.080 (0.069, 0.092)

5.4

< 0.001

 LDL-C

0.084 (0.073, 0.097)

0.003 (0.001, 0.004)

0.082 (0.070, 0.094)

3.1

0.002

 Non-HDL-C

0.084 (0.073, 0.096)

0.004 (0.002, 0.006)

0.080 (0.069, 0.093)

4.9

< 0.001

 RC

0.084 (0.073, 0.096)

0.011 (0.009, 0.013)

0.073 (0.062, 0.086)

12.9

< 0.001

 TC/HDL-C ratio

0.084 (0.073, 0.096)

0.010 (0.007, 0.012)

0.075 (0.063, 0.087)

11.5

< 0.001

 TG/HDL-C ratio

0.084 (0.073, 0.096)

0.011 (0.008, 0.013)

0.074 (0.062, 0.086)

12.5

< 0.001

 LDL/HDL-C ratio

0.084 (0.073, 0.096)

0.008 (0.006, 0.011)

0.076 (0.064, 0.089)

9.8

< 0.001

 Non-HDL-C/HDL-C ratio

0.084 (0.073, 0.096)

0.010 (0.007, 0.012)

0.075 (0.063, 0.087)

11.5

< 0.001

 RC/HDL-C ratio

0.084 (0.073, 0.096)

0.013 (0.010, 0.016)

0.071 (0.060, 0.084)

15.4

< 0.001

  1. PM: propotion mediate; other abbreviations as in Table 1
  2. Adjusting variables: age, WC, SBP, DBP, ALT, AST, GGT, FPG, HbA1c, habit of exercise, smoking status and drinking status