Mediator | Total effect | Mediation effect | Direct effect | PM (%) | P-value of PM |
---|---|---|---|---|---|
Men (n = 7441) |  |  |  |  |  |
 TC | 0.110 (0.088, 0.132) | 0.001 (0.000, 0.002) | 0.109 (0.087, 0.131) | 1 | 0.006 |
 TG | 0.110 (0.087, 0.132) | 0.005 (0.001, 0.008) | 0.105 (0.083, 0.128) | 4.4 | < 0.001 |
 HDL-C | 0.111 (0.088, 0.133) | 0.004 (0.002, 0.007) | 0.106 (0.084, 0.128) | 3.9 | < 0.001 |
 LDL-C | 0.110 (0.088, 0.132) | 0.002 (0.001, 0.003) | 0.108 (0.086, 0.131) | 1.7 | < 0.001 |
 Non-HDL-C | 0.110 (0.087, 0.132) | 0.004 (0.002, 0.006) | 0.107 (0.084, 0.129) | 3.2 | < 0.001 |
 RC | 0.110 (0.087, 0.132) | 0.007 (0.003, 0.010) | 0.104 (0.081, 0.126) | 5.9 | < 0.001 |
 TC/HDL-C ratio | 0.111 (0.088, 0.133) | 0.008 (0.005, 0.011) | 0.103 (0.080, 0.125) | 7 | < 0.001 |
 TG/HDL-C ratio | 0.111 (0.088, 0.132) | 0.006 (0.003, 0.010) | 0.105 (0.082, 0.127) | 5.5 | < 0.001 |
 LDL/HDL-C ratio | 0.111 (0.088, 0.132) | 0.007 (0.004, 0.009) | 0.104 (0.082, 0.127) | 5.9 | < 0.001 |
 Non-HDL-C/HDL-C ratio | 0.111 (0.088, 0.133) | 0.008 (0.005, 0.011) | 0.103 (0.080, 0.125) | 7 | < 0.001 |
 RC/HDL-C ratio | 0.111 (0.088, 0.132) | 0.008 (0.005, 0.012) | 0.102 (0.080, 0.125) | 7 | < 0.001 |
Women (n = 6840) |  |  |  |  |  |
 TC | 0.084 (0.073, 0.097) | 0.001 (0.000, 0.002) | 0.083 (0.072, 0.096) | 1 | 0.046 |
 TG | 0.084 (0.073, 0.096) | 0.010 (0.008, 0.012) | 0.074 (0.063, 0.087) | 11.7 | < 0.001 |
 HDL-C | 0.084 (0.073, 0.097) | 0.005 (0.003, 0.006) | 0.080 (0.069, 0.092) | 5.4 | < 0.001 |
 LDL-C | 0.084 (0.073, 0.097) | 0.003 (0.001, 0.004) | 0.082 (0.070, 0.094) | 3.1 | 0.002 |
 Non-HDL-C | 0.084 (0.073, 0.096) | 0.004 (0.002, 0.006) | 0.080 (0.069, 0.093) | 4.9 | < 0.001 |
 RC | 0.084 (0.073, 0.096) | 0.011 (0.009, 0.013) | 0.073 (0.062, 0.086) | 12.9 | < 0.001 |
 TC/HDL-C ratio | 0.084 (0.073, 0.096) | 0.010 (0.007, 0.012) | 0.075 (0.063, 0.087) | 11.5 | < 0.001 |
 TG/HDL-C ratio | 0.084 (0.073, 0.096) | 0.011 (0.008, 0.013) | 0.074 (0.062, 0.086) | 12.5 | < 0.001 |
 LDL/HDL-C ratio | 0.084 (0.073, 0.096) | 0.008 (0.006, 0.011) | 0.076 (0.064, 0.089) | 9.8 | < 0.001 |
 Non-HDL-C/HDL-C ratio | 0.084 (0.073, 0.096) | 0.010 (0.007, 0.012) | 0.075 (0.063, 0.087) | 11.5 | < 0.001 |
 RC/HDL-C ratio | 0.084 (0.073, 0.096) | 0.013 (0.010, 0.016) | 0.071 (0.060, 0.084) | 15.4 | < 0.001 |