Fig. 9

Administration of the specific CCR5 agonist rCCL5 exacerbated cerebral damage via the JAK2/STAT3/MMP9 signaling pathway 3 days after ICH and induction of severe peripheral inflammation. A EB fluorescence images (scale bar = 50 μm) and trajectories in the OFT. According to the preset parameters, the mouse trajectories are presented in three colors: black (low speed), green (middle speed), and red (high speed). B–E Western blot images and quantitative analysis of p-JAK2, p-STAT3, and MMP9 levels in the ipsilateral hemisphere in the sham, ICH, ICH + LPS, ICH + LPS + vehicle, and ICH + LPS + rCCL5 groups 3 days after ICH. G, H Statistical analysis of average velocity and BMS scores. The data are expressed as the mean ± SD. ^# vs. the sham group, P < 0.05; ^c vs. the ICH + LPS group, P < 0.05; ^d vs. the ICH + LPS + vehicle group, P < 0.05; ^& vs. the ICH group, P < 0.05; ns: no significance