Fig. 4
From: EGR1 induces EMT in pancreatic cancer via a P300/SNAI2 pathway
SNAI2 was a direct target of EGR1 in pancreatic cancer. A The predicted RNA correlation of EGR1 and SNAI1, SNAI2, ZEB1 in pancreatic cancer. B and C QPCR analysis showed the relative expression of the above genes after knockdown and overexpression of EGR1. D ChIP-qPCR assay showed the binding capability of EGR1 with different predicted binding sites. E Dual-luciferase reporter assay indicated the promoter activity of SNAI2 encoding wild-type (WT) or mutant EGR1-binding site (MUT). F A schematic depicting EGR1 bound with SNAI2 promoter to activate SNAI2 transcription. ***: p < 0.001