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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility

Fig. 1

Schematic overview of the various approaches developed to modulate CAR T cell activities as discussed in this review. Six broad categories are discussed: (1) Elimination of therapeutic cells, (2) Regulation of CAR gene expression, (3) Inducible CAR protein degradation, (4) Inducible formation of a functional CAR or inducible CAR disassembly, (5) Inhibitory CARs, and (6) Modular universal adaptor CAR platforms. CID, chemical inducer of dimerization

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Journal of Translational Medicine

ISSN: 1479-5876

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