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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Identification of FCN1 as a novel macrophage infiltration-associated biomarker for diagnosis of pediatric inflammatory bowel diseases

Fig. 1

Identification of FCN1 as a candidate biomarker for PIBD diagnosis. A Overall workflow for construction and external validation of the diagnostic model. B Volcano plot of differentially expressed genes (DEGs) between PIBD and non-IBD rectal biopsy samples of GSE117993. Genes with adjusted P < 0.05 and |log2(Fold Change)|> 2 are considered as DEGs, and these DEGs are listed in Table S1. C LASSO logistic regression algorithm for biomarker selection. D mSVM-RFE algorithm for biomarker selection. E Venn diagram visualizing the overlap of selected markers between two algorithms. Receiver operating characteristic (ROC) curves and the corresponding area under the curves (AUCs) of diagnostic prediction models based on FCN1 and LINC01558 in the colon F and blood G validation datasets (GSE126124)

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