Fig. 10

Pharmacogenetic analysis identified pyridostatin as a potent drug for high IMMT expression. A–J Identification of pyridostatin as a potential drug candidate. Scatter plot showing scores of predictivity and descriptivity for drugs acting on BC cells with various single guide IMMT (sgIMMT) efficacy. Dots in red and blue represent hits with a predictivity p-value of < 0.05 and a descriptivity p-value of 0.05 (A). Boxplots showing –log (IC50) M of AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) (B), MK-1775(C), luminespib (D), ulixertinib (E), camptothecin (F), wee1 inhibitor (G), and pyridostatin (H). *p < 0.05, **p < 0.01, ***p < 0.001 between indicated groups. Dot plots showing the correlation of pyridostatin sensitivity with IMMT expression (I) and with IMMT copy number (J)