Fig. 8From: miRNA-seq identification and clinical validation of CD138+ and circulating miR-25 in treatment response of multiple myelomaCirculating miR-25 is associated with aggressive disease phenotype and poor survival. A–D Box plots presenting the correlation of plasma miR-25 levels with R-ISS stage A, high risk cytogenetics B B2M levels C and creatinine levels D in the screening MM cohort. p-values calculated by Kruskal–Wallis test A and Mann–Whitney U test B–D. E Kaplan–Meier survival curves for overall survival (OS) of the MM screening cohort. p-value calculated by log-rank test. Forest plot of the univariate F Cox proportional regression analysis. Internal validation was performed by bootstrap analysis based on 1000 bootstrap samples. HR: Hazard Ratio, 95% CI: 95% confidence interval of the estimated HRBack to article page