Fig. 2

miRNA-seq of CD138+ plasma cells and MM prognosis. A Flow diagram of miRNA-seq analysis of CD138+ plasma cells in MM and sMM patients, B, C Venn diagrams depicting shared miRNAs in B MM vs. sMM and C R-ISS I vs. R-ISS II/III patients. D, E Bar graphs of miRNAs log2FC in D MM vs. sMM and E R-ISS II/III vs. R-ISS I stages. F Heatmap of the mutually deregulated miRNAs in a. MM vs. sMM, b. R-ISS II/III vs. R-ISS I and c. progressed vs. non-progressed patients displaying FC ≥ 1.5 or ≤ 0.67. Colorgram illustrates high (red) and low (blue) miRNA expression levels. G Kaplan–Meier survival curves of Kryukov et al. MM cohort, according to CD138+ miR-25-3p expression. p-value calculated by log-rank test. FC: fold change