Fig. 2

Identification of DEGs related to mitochondrion and construction of prognostic risk model using TCGA-STAD cohort. A Volcano plot of 2381 DEGs in STAD tumor and normal groups. B Venn diagram showed that the overlap of 2381 DEGs and 2030 mitochondrial genes led to 183 hub genes being identified. C Univariate Cox regression analysis revealed 19 genes were associated with prognosis of patients with STAD. D LASSO regression of the 19 OS-related genes. Cross-validation in the LASSO regression model to select the tuning parameter. The abscissa shows the log (λ) value, and the ordinate shows partial likelihood deviance. The red dots in the figure show partial likelihood deviations ± standard error for diverse tuning parameters. E Multivariable Cox regression analysis revealed 4 genes were associated with prognosis of patients with STAD. F Gene expressions of the 4 prognosis-related genes in TCGA-STAD. P values were showed as: ***P < 0.001