Table 2 Significant hypermethylated genes in primary human cardiac fibroblasts after high-intensity interval training (HIIT)
Entrez Gene | Protein Name | Gene Name | FC | Predicted Cellular Behaviour | ||
|---|---|---|---|---|---|---|
Movement | Death | Proliferation | ||||
37 | Acyl-CoA Dehydrogenase Very Long Chain | ACADVL | 4.4742 | ↓ | ↑ | ↓ |
8851 | Cyclin-Dependent Kinase 5 Regulatory Subunit 1 | CDK5R1 | 4.2352 | ↓ | ↑ | ↓ |
9693 | Rap Guanine Nucleotide Exchange Factor 2 | RAPGEF2 | 3.2325 | ↓ | ↑ |  |
3778 | Potassium Calcium-Activated Channel Subfamily M Alpha 1 | KCNMA1 | 2.0538 | ↓ | ↑ |  |
27 | ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase | ABL2 | 2.5627 | ↓ | ↑ |  |
50,509 | Collagen Type V Alpha 3 Chain | COL5A3 | 1.8299 | ↓ | ↑ |  |
56,606 | Solute Carrier Family 2 Member 9 | SLC2A9 | 2.0983 | ↓ | ↑ |  |
3594 | Interleukin 12 Receptor Subunit Beta 1 | IL12RB1 | 1.7534 | ↓ | ↑ |  |
4683 | Nibrin | NBN | 1.9575 | ↓ | ↑ |  |
1387 | CREB Binding Protein | CREBBP | 1.6711 | ↓ | ↑ |  |
9793 | Cytoskeleton-Associated Protein 5 | CKAP5 | 1.8684 | ↓ | ↑ |  |
168,667 | BMP Binding Endothelial Regulator | BMPER | 1.9241 | ↓ | ↑ |  |
8409 | Ubiquitously Expressed Prefoldin-Like Chaperone | UXT | 1.8092 | ↓ | ↑ |  |
2353 | Fos Proto-Oncogene, AP-1 Transcription Factor Subunit | FOS | 1.7576 | ↓ | ↑ |  |
7087 | Intercellular Adhesion Molecule 5 | ICAM5 | 1.7978 | ↓ |  | ↓ |
5872 | Ras-Related Protein Rab-13 | RAB13 | 1.7113 | ↓ |  | ↓ |
85,458 | DIX Domain Containing 1 | DIXDC1 | 2.1024 | ↓ |  | ↓ |
1809 | Dihydropyrimidinase Like 3 | DPYSL3 | 2.6682 | ↓ |  | ↓ |
1326 | Mitogen-Activated Protein Kinase Kinase Kinase 8 | MAP3K8 | 4.4278 |  | ↑ | ↓ |
10,818 | Fibroblast Growth Factor Receptor Substrate 2 | FRS2 | 1.9999 |  | ↑ | ↓ |
343,472 | BarH Like Homeobox 2 | BARHL2 | 1.9680 | ↓ |  |  |
5195 | Peroxisomal Biogenesis Factor 14 | PEX14 | 1.6785 | ↓ |  |  |
9645 | Microtubule-Associated Monooxygenase, Calponin And LIM Domain Containing 2 | MICAL2 | 1.9794 | ↓ |  |  |
64,225 | Atlastin GTPase 2 | ATL2 | 1.9992 | ↓ |  |  |
23,336 | Synemin | SYNM | 2.4273 | ↓ |  |  |
23,031 | Microtubule-Associated Serine/Threonine Kinase 3 | MAST3 | 1.7534 | ↓ |  |  |
64,083 | Golgi Phosphoprotein 3 | GOLPH3 | 2.2160 | ↓ |  |  |
9138 | Rho Guanine Nucleotide Exchange Factor 1 | ARHGEF1 | 3.2940 | ↓ |  |  |
10,540 | Dynactin Subunit 2 | DCTN2 | 2.1330 | ↓ |  |  |
10,434 | Lysophospholipase 1 | LYPLA1 | 2.5174 | ↓ |  |  |
6809 | Syntaxin 3 | STX3 | 2.8263 | ↓ |  |  |
4750 | NIMA-Related Kinase 1 | NEK1 | 2.0534 | ↓ |  |  |
10,961 | Endoplasmic Reticulum Protein 29 | ERP29 | 2.4136 | ↓ |  |  |
79,734 | Potassium Channel Tetramerization Domain Containing 17 | KCTD17 | 4.0509 | ↓ |  |  |
55,186 | Solute Carrier Family 25 Member 36 | SLC25A36 | 2.2247 | ↓ |  |  |
50,650 | Rho Guanine Nucleotide Exchange Factor 3 | ARHGEF3 | 1.8849 | ↓ |  |  |
4147 | Matrilin 2 | MATN2 | 2.8825 | ↓ |  |  |
7205 | Thyroid Hormone Receptor Interactor 6 | TRIP6 | 1.9351 | ↓ |  |  |
57,701 | NCK-Associated Protein 5 Like | NCKAP5L | 1.8715 | ↓ |  |  |
64,223 | MTOR-Associated Protein, LST8 Homologue | MLST8 | 1.8991 | ↓ |  |  |
23,647 | ADP Ribosylation Factor Interacting Protein 2 | ARFIP2 | 2.4137 | ↓ |  |  |
11,019 | Lipoic Acid Synthetase | LIAS | 3.2797 |  | ↑ |  |
3169 | Forkhead Box A1 | FOXA1 | 2.9653 |  | ↑ |  |
175 | Aspartylglucosaminidase | AGA | 2.7531 |  | ↑ |  |
23,600 | Alpha-Methylacyl-CoA Racemase | AMACR | 2.2991 |  | ↑ |  |
9643 | Mortality Factor 4 Like 2 | MORF4L2 | 2.2689 |  | ↑ |  |
58,524 | Doublesex and Mab-3 Related Transcription Factor 3 | DMRT3 | 2.0777 |  | ↑ |  |
3183 | Heterogeneous Nuclear Ribonucleoprotein C | HNRNPC | 1.9362 |  | ↑ |  |
8567 | MAP Kinase Activating Death Domain | MADD | 1.8934 |  | ↑ |  |
10,195 | ALG3 Alpha-1,3- Mannosyltransferase | ALG3 | 1.8191 |  | ↑ |  |
9646 | CTR9 Homologue, Paf1/RNA Polymerase II Complex Component | CTR9 | 1.7912 |  | ↑ |  |
3382 | Islet Cell Autoantigen 1 | ICA1 | 1.6084 |  | ↑ |  |
4047 | Lanosterol Synthase | LSS | 0.5589 |  | ↑ |  |
8325 | Frizzled Class Receptor 8 | FZD8 | 2.1777 |  |  | ↓ |
55,553 | SRY-Box Transcription Factor 6 | SOX6 | 1.6703 |  |  | ↓ |