Hypermethylation of ACADVL is involved in the high-intensity interval training-associated reduction of cardiac fibrosis in heart failure patients

Table 1 Effects of high-intensity interval training (HIIT) on aerobic capacity and quality of life

Assessment		Pre-HIIT	Post-HIIT	p value
Aerobic Capacity	\(\normalsize \tt V\)O_2peak, O₂ mL/min/kg	19.0 ± 1.1	21.8 ± 1.1	0.009*
	CO_ex, L/min	10.1 ± 0.6	11.3 ± 0.7	0.036*
	OUES, O₂ ml/min/log (L/min)	664 ± 51	710 ± 52	0.023*
SF-36	PCS	51.6 ± 2.0	54.5 ± 1.4	0.158
SF-36	MCS	46.1 ± 2.7	50.5 ± 1.9	0.182
CMR Image	LV mass, g	119 ± 18	119 ± 12	0.721
	CO_rest, L/min	4.3 ± 0.3	5.2 ± 0.3	0.182
	LVESV, mL	82.7 ± 20	51.4 ± 15	0.006*
	LVEDV, mL	139 ± 22	118 ± 18	0.033*
	LVEF, %	45.9 ± 4.5	59.8 ± 3.7	0.010*
	LVWMS	28.7 ± 1.4	22.3 ± 1.6	0.012†
Cardiac Stress	BNP, pg/mL	99.0 ± 29	24.8 ± 5.8	0.003*

Data are shown as the mean ± SEM
BNP b-type natriuretic peptide, CMR cardiovascular magnetic resonance, CO cardiac output, CO_ex CO during exercise, CO_rest resting CO, EF ejection fraction, EDV end-diastolic volume, ESV end-systolic volume, HIIT high-intensity interval training, LV left ventricle, MCS mental component score, PCS physical component score, OUES oxygen uptake efficient slope, QoL quality of life, SEM standard error of mean, SF-36 short form 36 questionnaire, \(\normalsize \tt V\)_E minute ventilation, \(\normalsize \tt V\)O_2peak peak oxygen consumption, WMS wall motion score
Significant difference between pre- and post-HIIT: Wilcoxon signed rank test (^*), chi-square test (^†)

ISSN: 1479-5876