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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Targeting KK-LC-1 inhibits malignant biological behaviors of triple-negative breast cancer

Fig. 7

Drug susceptibility test of Z8 small-molecule compound in different breast cancer cell lines. And the inhibitory effect of Z8 on malignant biological behaviors of triple-negative breast cancer cells. A Z8 small-molecule compound molecular structure. B, C Molecular docking assay to analyze the binding ability of Z8 to KK-LC-1 pure protein. D Calculation of EC50 values of Z8 in MDA-MB-231 cells. E Calculation of EC50 values of Z8 in MDA-MB-468 cells. F Analysis of the inhibition rate of MCF7 cell proliferation by Z8 at different concentrations. G Analysis of the inhibition rate of SKBR3 cell proliferation by Z8 at different concentrations. H Analysis of the inhibition rate of MDA-MB-231/KD cell proliferation by Z8 at different concentrations. I Inhibitory effect of Z8 on the cell proliferation. J Inhibitory effect of Z8 on the wound healing ability. K Inhibitory effect of Z8 on the invasive ability. L Inhibitory effect of Z8 on the migration ability. M Z8 promotes apoptosis. N Z8 blocks cell cycle. (**P < 0.01)

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