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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Targeting KK-LC-1 inhibits malignant biological behaviors of triple-negative breast cancer

Fig. 5

KK-LC-1 regulates the malignant biological behaviors of triple-negative breast cancer cells through the MAL2/MUC1-C/PI3K/AKT/mTOR pathway. A, B Detection of KK-LC-1, MAL2, MUC1-C, PI3K, p-PI3K, AKT, p-AKT, mTOR, and p-mTOR expression in MDA-MB-231/NC and MDA-MB-231/KD cells using western blotting (**P < 0.01). C, D Detection of KK-LC-1, MAL2, MUC1-C, PI3K, p-PI3K, AKT, p-AKT, mTOR, and p-mTOR expression in MDA-MB-468/NC and MDA-MB-468/KD cells using western blotting (**P < 0.01). E, F Detection of KK-LC-1, MAL2, MUC1-C, PI3K, p-PI3K, AKT, p-AKT, mTOR, and p-mTOR expression in MDA-MB-231/NC, MDA-MB-231/KD, MDA-MB-231/KDOE_NC, and MDA-MB-231/KDOE_MAL2 cells using western blotting (**P < 0.01). MDA-MB-231/KDOE_NC cells: a group of empty plasmid-transfected KK-LC-1-silenced MDA-MB-231 cell lines. MDA-MB-231/KDOE_MAL2 cells: a group of MAL2 overexpression plasmid-transfected KK-LC-1-silenced MDA-MB-231 cell lines G, H Detection of KK-LC-1, MAL2, MUC1-C, PI3K, p-PI3K, AKT, p-AKT, mTOR, and p-mTOR expression in MDA-MB-468/NC, MDA-MB-468/KD, MDA-MB-468/KDOE_NC, and MDA-MB-468/KDOE_MAL2 cells using western blotting (**P < 0.01). MDA-MB-468/KDOE_NC cells: a group of empty plasmid-transfected KK-LC-1-silenced MDA-MB-468 cell lines. MDA-MB-468/KDOE_MAL2 cells: a group of MAL2 overexpression plasmid-transfected KK-LC-1-silenced MDA-MB-468 cell lines

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