Fig. 6

At an advanced stage, Il-12 reverses the shift of Th1/Th2 immune balance to Th2 accumulation. The mice in the AML group were sacrificed 7 weeks after AOM administration, and naïve primary T cells were extracted from the spleen of mice A Flow cytometry analysis of the mean percentage of Th1, Th2 and Treg cells in naïve CD4⁺T cells co-cultured with MSCs (ratio 1:5) or with MSCs/IL-12(10 ng/ml) for 72 h respectively. B Analyze and count separately. Values are expressed as means ± SD. *P < 0.05, **P < 0.01. TM: CD4⁺T cells co-cultured with MSCs for 72 h; TMI: CD4⁺T cells co-cultured with MSCs (ratio 1:5)/IL-12(10 ng/ml)