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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Mesenchymal stem cells can prevent or promote the progression of colon cancer based on their timing of administration

Fig. 1

MSCs affect the growth of colon cancers brought on by AOM/DSS. A After AOM injection, animals were subjected to three cycles of DSS. MSCs during the study period, the AME group was injected (2 × 106 cells/mouse) per week from week 1, while the AML group was injected (2 × 106 cells/mouse) per week from week 7. Every week, mice in the CON group received an intraperitoneal injection of 0.2 mL of pure PBS. Animals were sacrificed under anesthesia at week 14 (n = 15/group). B Colons were excised for macroscopic observation and C slices were stained with H&E observed using the light microscope. D The survival rate and E weight of mice in each group was noted and compared. F Colon length, G tumor numbers, and H tumor numbers counted by size were assessed. I Colon tissues were collected to detect the migration of MSCs in the DSS/AOM-induced model. Data are shown as mean ± SD from three independent experiments. ***P < 0.001, **P < 0.01, *P < 0.05

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