Table 4 Genes promoter hypermethylated/ hypomethylated in organ fibrosis
Organ | Genes |
|---|---|
Lung | Thy-1 [154, 155], PTGER2 [158], C8ORF4 [157], TSC1/TSC2 [162], BMPER [163], p14ARF [168], CDKN2B [171] |
Heart | Rasal1 [149, 150], COL1A1(hypomethylated) [174, 175], α-SMA(hypomethylated) [174] |
Liver | PTEN [152], PPARγ [152, 153], RCAN1.4 [165], SUN2 [166], SEPT9 [167], SMAD7 [169] |
Kidney | Rasal1 [143, 147, 148], Klotho [151], SMAD7 [170], sFRP5 [161], KLF4 [172] |
Skin |