Table 2 Mechanisms of chromatin remodeler BRG1 in organ fibrosis
Organ | Cell | Co-factors | Target genes | Transcriptional regulation | Effect on fibrosis | Refs. |
|---|---|---|---|---|---|---|
Heart | Endothelial cell | Sp1, SRF | SNAI2, COL1A2 | Activation | Pro | [28] |
Heart | Endothelial cell | Ash2, MRTF-A | ET-1 | Repression | Pro | [29] |
Kidney | Endothelial cell | Smad3 | IL-33 | Activation | Pro | [34] |
Liver | Endothelial cell | Sp1 | CAV-1 | Activation | Pro | [30] |
Liver | Endothelial cell | HIF-1α | TWIST | Repression | Pro | [31] |
Liver | Endothelial cell | Smad3, AP-1 | NOX4 | Repression | Pro | [32] |
Liver | Hepatic stellate cell | HIF-1α, p300, ASH2, KDM3A | α-SMA, COL1A1 | Activation | Pro | [36] |