Table 1 Common clinical disease models and animal models in organ fibrosis
Organ | Clinical disease models | Animal models |
|---|---|---|
Lung | Idiopathic pulmonary fibrosis (IPF), radiation induced pulmonary fibrosis | Bleomycin induced pulmonary fibrosis |
Heart | Myocardial infarction (MI) cardiomyopathy, chronic heart failure | MI induced cardiac fibrosis, transverse aortic constriction (TAC) induced cardiac fibrosis, Ang-II induced cardiac fibrosis |
Liver | Non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) viral hepatitis | CCl4 induced liver fibrosis, thioacetamide (TAA) induced liver fibrosis, bile duct ligation (BDL) induced liver fibrosis |
Kidney | Chronic kidney disease (CKD) easpecially diabetic and hypertrophic nephropathy | Ischemia–reperfusion injury (IRI) induced renal fibrosis, unilateral ureteral obstruction (UUO) induced renal fibrosis |
Skin | Systemic Sclerosis (SSc), hypertrophic scar and keloid | Bleomycin induced skin fibrosis |