Fig. 9

Working Model: The spatiotemporal matching pattern of Ezrin/Periaxin was involved in muscle repair in a peroneal nerve injury model. Instantaneous L-periaxin expression was highest on the 6th day, while Ezrin expression peaked on the 4th day during myoblast differentiation/fusion (A). Ezrin promoted myoblast differentiation/fusion, myotube length and size, and myofiber specialization. L-periaxin acted as a brake for myotube length and size, negatively regulating the effect of Ezrin on myotube formation (A, B). The effects of Ezrin were related to the activated PKA-NFAT-MyoD/MEF2C signaling pathway (C). Combined gene therapy with Ezrin and L-periaxin contributed to muscle repair in a peroneal nerve injury model (D), providing a novel therapeutic strategy for the treatment of nerve injury, especially CMT4F-associated muscle atrophy