Fig. 4

Intratumoral effectiveness of RB‐312 against FaDu xenograft. A Scatter plot for tumor growth at day 30 (0.3 M CAR‐T cell dose). B RB‐312 effect on survival—survival analysis until day 45. Survival was significantly increase in mice injected with RB-312. C Intratumoral persistence of CAR‐T cells at necropsy D PD1 expression by intratumoral CAR-T cells at necropsy showed that RB-312 displays significantly higher PD1 surface markers. E Retention samples from the animal study were stimulated with HER2-coated beads and analysis of IL-12/p70 expression, PD1 expression, IFN‐γ, IL-2 and TNF‐α secretion was performed