MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey

Yan, Wenying; Chen, Yuqi; Hu, Guang; Shi, Tongguo; Liu, Xingyi; Li, Juntao; Sun, Linqing; Qian, Fuliang; Chen, Weichang

doi:10.1186/s12967-023-04010-z

Table 2 Association of miRNAs and lncRNAs in miR-200/183 family-mediated module with clinic pathological characteristics of GC patients from TCGA

From: MiR-200/183 family-mediated module biomarker for gastric cancer progression: an AI-assisted bioinformatics method with experimental functional survey

Characteristics	Total	miR-182-5p			miR-183-5p			miR-200b-3p			miR-141-3p			miR-200c-3p			miR-200a-3p			miR-429			CLLU1			H19
Characteristics	Total	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p	High	Low	p
Age
≤ 60	89	36	53	0.004*	37	52	0.009*	39	50	0.006*	42	47	0.041*	39	50	0.011*	39	50	0.002*	42	47	0.033*	22	67	0.433	14	75	0.266
> 60	168	101	67		100	68		105	63		103	65		103	65		109	59		104	64		33	135		17	151
Gender
Female	99	53	46	1.000	54	45	0.852	56	43	0.994	56	43	1.000	51	48	0.409	59	40	0.699	59	40	0.559	24	75	0.470	13	86	0.826
Male	158	84	74		83	75		88	70		89	69		91	67		89	69		87	71		31	127		18	140
TNM stage
I	35	28	7	0.003*	27	8	0.007*	28	7	0.006*	27	8	0.039*	29	6	0.001*	26	9	0.193	28	7	0.028*	4	31	0.369	2	33	0.193
II	94	51	43		52	42		50	44		53	41		50	44		52	42		51	43		19	75		8	86
III	103	45	58		45	58		57	46		54	49		55	48		57	46		53	50		26	77		17	86
IV	25	13	12		13	12		9	16		11	14		8	17		13	12		14	11		6	19		4	21
T
T1	10	10	0	0.001*	10	0	0.003*	10	0	0.002*	10	0	0.003*	10	0	0.002*	9	1	0.053	9	1	0.006*	0	10	0.290	0	10	0.068
T2	64	42	22		40	24		43	21		43	21		42	22		42	22		45	19		13	51		3	61
T3	106	53	53		53	53		49	57		56	50		56	50		55	51		54	52		22	84		18	88
T4	77	32	45		34	43		42	35		36	41		34	43		42	35		38	39		20	57		10	67
N
N0	87	54	33	0.249	51	36	0.655	56	31	0.208	52	35	0.256	56	31	0.177	54	33	0.793	52	35	0.874	17	70	0.664	8	79	0.692
N1	75	36	39		39	36		37	38		45	30		40	35		41	34		43	32		15	60		9	66
N2	44	23	21		23	21		22	22		26	18		23	21		25	19		23	21		9	35		7	37
N3	50	24	26		24	26		29	21		22	28		23	27		28	22		28	22		14	36		7	43
M
M0	230	126	104	0.195	125	105	0.207	130	100	0.533	133	97	0.324	131	99	0.255	133	97	0.971	131	99	0.246	50	180	0.568	27	203	0.674
M1	16	8	8		9	7		7	9		8	8		6	10		9	7		11	5		4	12		3	13
Mx	11	3	8		3	8		7	4		4	7		5	6		6	5		4	7		1	10		1	10
Type
Diffuse	49	21	28	0.212	19	30	0.023*	23	26	0.178	24	25	0.108	22	27	0.076	23	26	0.149	23	26	0.059	17	32	0.041*	4	45	0.636
Intestinal	89	52	37		56	33		56	33		58	31		57	32		57	32		59	30		16	73		12	77
Others	119	64	55		62	57		65	54		63	56		63	56		68	51		64	55		22	97		15	104
Grade
G1	3	0	3	0.056	1	2	0.029*	0	3	0.029*	1	2	0.034*	0	3	0.000*	0	3	0.030*	2	1	0.226	0	3	0.044*	1	2	0.631
G2	79	48	31		52	27		53	26		55	24		58	21		54	25		52	27		9	70		10	69
G3	170	88	82		83	87		88	82		87	83		81	89		91	79		90	80		45	125		19	151
Gx	5	1	4		1	4		3	2		2	3		3	2		3	2		2	3		1	4		1	4

T: Primary tumor invasion depth; N: Lymph node metastasis; M: Distant metastasis
^*p-value < 0.05

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