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Table 2 cox regression analysis of FPG versus T2D

From: J-shape relationship between normal fasting plasma glucose and risk of type 2 diabetes in the general population: results from two cohort studies

 

Crude model

Minimally model

Fully model

HR (95%CI)

P-value

HR (95%CI)

P-value

HR (95%CI)

P-value

All populations

 FPG

9.28 (8.5, 10.13)

 < 0.001

6.5 (5.95, 7.1)

 < 0.001

5.8 (5.31, 6.33)

 < 0.001

FPG Quintiles

 Q1

Reference

 

Reference

 

Reference

 

 Q2

1.24 (1, 1.54)

0.049

1.16 (0.94, 1.44)

0.175

1.22 (0.98, 1.52)

0.072

 Q3

2.01 (1.65, 2.46)

 < 0.001

1.77 (1.45, 2.17)

 < 0.001

1.81 (1.48, 2.21)

 < 0.001

 Q4

3.17 (2.64, 3.82)

 < 0.001

2.55 (2.12, 3.07)

 < 0.001

2.79 (2.32, 3.37)

 < 0.001

 Q5

12.73 (10.8, 15)

 < 0.001

8.42 (7.13, 9.95)

 < 0.001

8.07 (6.82, 9.56)

 < 0.001

 P for trend

 < 0.001

 

 < 0.001

 

 < 0.001

 

Chinese

 FPG

9.73 (8.9, 10.64)

 < 0.001

6.8 (6.21, 7.44)

 < 0.001

5.5 (5.02, 6.02)

 < 0.001

FPG Quintiles

 Q1

Reference

 

Reference

 

Reference

 

 Q2

1.4 (1.12, 1.76)

0.003

1.3 (1.04, 1.63)

0.022

1.23 (0.98, 1.55)

0.07

 Q3

2.38 (1.93, 2.93)

 < 0.001

2.08 (1.69, 2.56)

 < 0.001

1.85 (1.5, 2.27)

 < 0.001

 Q4

4.1 (3.38, 4.98)

 < 0.001

3.28 (2.7, 3.99)

 < 0.001

2.83 (2.32, 3.43)

 < 0.001

 Q5

16.8 (14.16, 19.93)

 < 0.001

10.89 (9.16, 12.94)

 < 0.001

8.26 (6.93, 9.83)

 < 0.001

 P for trend

 < 0.001

 

 < 0.001

 

 < 0.001

 

 FPG

25.38 (18.71, 34.42)

 < 0.001

21.83 (15.9, 29.98)

 < 0.001

14.57 (10.48, 20.25)

 < 0.001

Japanese

 FPG Quintiles

  Q1

Reference

 

Reference

 

Reference

 

  Q2

1.98 (0.95, 4.13)

0.069

1.89 (0.91, 3.96)

0.09

1.84 (0.86, 3.91)

0.115

  Q3

2.89 (1.45, 5.77)

0.003

2.67 (1.33, 5.37)

0.006

2.3 (1.12, 4.72)

0.023

  Q4

6.53 (3.44, 12.37)

 < 0.001

5.88 (3.07, 11.29)

 < 0.001

4.55 (2.31, 8.95)

 < 0.001

  Q5

26.24 (14.34, 48)

 < 0.001

22.08 (11.85, 41.15)

 < 0.001

14.21 (7.4, 27.28)

 < 0.001

  P for trend

 < 0.001

 

 < 0.001

 

 < 0.001

 
  1. Statistical analysis method used: cox regression analysis
  2. Bold values indicate the statistically significant P values
  3. Crude model: unadjusted; Minimally model: adjusted for age and sex; Fully model: adjusted for age, sex, BMI, SBP, DBP, TC, TG, ALT, smoking, and drinking. All populations additional adjusted for country
  4. T2D type 2 diabetes, FPG fasting plasma glucose, HR hazard ratio, CI confidence interval
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Journal of Translational Medicine

ISSN: 1479-5876

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