The relationship of reproductive factors with adiposity and body shape indices changes overtime: findings from a community-based study

Table 3 Effects of menopausal age on adiposity indices in women of the TLGS over time

Reproductive factors	Outcomes	Model 1	P-value ^c	Model 2	P-value ^c
Reproductive factors	Outcomes	Coefficient (95% CI)	P-value ^c	Coefficient (95% CI)	P-value ^c
Menopause age^a (ref: Normal)	BMI (kg/m²)
	Premature/early	0.37 (− 0.18, 0.92)	0.188	− 0.10 (− 0.67, 0.46)	0.722
	Late	− 0.13 (− 1.01, 0.75)	0.773	0.26 (− 0.62, 1.14)	0.566
	Time (year)	− 0.07 (− 0.12, − 0.02)	0.005	− 0.07 (− 0.11, − 0.02)	0.006
	Time × premature/early	0.10 (0.02, 0.19)	0.017	0.11 (0.02, 0.19)	0.012
	Time × late	− 0.10 (− 0.24, 0.04)	0.166	− 0.10 (− 0.24, 0.04)	0.163
	Waist circumference (cm)
	Premature/early	0.24 (− 1.10, 1.57)	0.723	0.26 (− 1.01, 1.63)	0.703
	Late	2.31 (0.19, 4.43)	0.033	2.27 (0.15, 4.39)	0.036
	Time	1.33 (1.18, 1.47)	< 0.001	1.34 (1.19, 1.48)	< 0.001
	Time × premature/early	0.07 (− 0.19, 0.32)	0.611	0.06 (− 0.19, 0.31)	0.643
	Time × late	− 0.27 (− 0.70, 0.15)	0.209	− 0.28 (− 0.70, 0.15)	0.200
	ABSI^b
	Early	− 0.10 (− 0.22, 0.02)	0.093	0.11 (− 0.007, 0.23)	0.066
	Late	0.37 (0.18, 0.56)	< 0.001	0.19 (0.01, 0.38)	0.037
	Time	0.21 (0.20, 0.23)	< 0.001	0.22 (0.20, 0.24)	< 0.001
	Time × premature/early	− 0.03 (− 0.05, − 0.0004)	0.047	− 0.03 (− 0.05, − 0.0009)	0.043
	Time × late	− 0.02 (− 0.06, 0.03)	0.390	− 0.02 (− 0.07, 0.02)	0.308

BMI Body mass index; ABSI A body shape index; Ref Reference; CI Confidence interval
Model 1: Unadjusted model
Model 2: Adjusted for baseline age, smoking, education, and physical activity status
Time variable means follow-up visits
^aAge at natural menopause was defined as younger than 40 years (premature menopause), 40–44 years (early menopause), 45–54 years (reference category), and 55 years or older (late menopause)
^bThe results of ABSI are presented by z-scores
^cSignificant p-values (p < 0.05) are bolded

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