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Table 3 Comparison of MET fusion sites of enrolled lung cancer patients according to the status of EGFR/ALK mutations

From: Identification of MET fusions as novel therapeutic targets sensitive to MET inhibitors in lung cancer

Fusion sites of MET

Primary MET fusions (n = 38)

Acquired MET fusions (n = 18)

 

Number

Location

Number

Location

Introns

25

NA

10

NA

Exons

13

 

6

 

 Exon2

1

Extracellular

/

/

 Exon3

/

/

2

Extracellular

 Exon4

/

/

1

Extracellular

 Exon6

/

/

1

Extracellular

 Exon10

1

Extracellular

/

/

 Exon11

1

Extracellular

1

Extracellular

 Exon12

2

Extracellular

/

/

 Exon13

1

Transmembrane

/

/

 Exon14

2

Cytoplasmic

/

/

 Exon15

1

Cytoplasmic

/

/

 Exon17

  

1

Cytoplasmic

 Exon19

2

Cytoplasmic

/

/

 Exon21

2

Cytoplasmic

/

/

NA

/

/

2

/

  1. NA not applicable