Fig. 4

Genomic changes associated with dysregulated TTK expression in EC. A Top 30 SMG in TCGA EC. B The difference in TMB between the TTK^high and TTK^low groups. ns not significant. C Forest plot of the top 20 differentially mutated genes between TTK^high and TTK^low groups. D Cobar plot of the top 20 differentially mutated genes between TTK^high and TTK^low groups. E Differential analysis of TTK expression in TCGA EC patients as divided by TP53 mutation status (wild type and mutants). ***P < 0.001, by Wilcoxon tests. F The upper and lower chromosomes plot show the CNV landscape in samples from the TTK^high and TTK^low groups, respectively