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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Integrated multi-omics analyses and functional validation reveal TTK as a novel EMT activator for endometrial cancer

Fig. 3

Involvement of TTK in the progression of the cell cycle in EC. A Heatmap shows the correlation of all modules and traits, with numbers in the modules indicating correlation coefficients and p-values. B KEGG enrichment analysis of genes in the modules revealed their biological functions. C Univariate cox regression analysis based on the mean expression of all genes in the modules. D Survival analysis of the green module gene set. A two-sided log-rank test is used to compare patient survival between the two groups. E The network plot shows the result of the protein–protein interaction analysis between the hub genes of the green module. F The scatter plot showed the correlation between GS values and MM of the green module; the horizontal red dashed line indicates GS = 0.2, and the vertical red dashed line indicates MM = 0.8. G Differential genes between the TTKhigh group and TTKlow groups; red dots indicate genes significantly overexpressed in the TTKhigh group, and blue dots indicate genes significantly overexpressed in the TTKlow group; the screening threshold is (log2|fold-change| > 1 and p-adjust < 0.05). The horizontal gray dashed line means p-adjust = 0.05, and the vertical gray dashed line means log2|fold-change| = 1. H Line chart illustrates the GSEA enrichment results; different colors indicate different hallmark terms

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