Fig. 3

Driver Assessment to DO classification workflow: the established workflow enables testing of the Complex Disease model through the identification of drivers for specific complex diseases. Assessment results in (1) identifying the genetics, epigenetics, social determinants of health, environmental drivers and other host factor drivers for a disease (2) updating the disease driver terms in the DO’s DISDRIV ontology, (3) revision of the DO classification (addition or removal of disease terms, defining, and (4) defining disease to driver relationships by including an ontology axiom statements to define the disease to driver association (e.g. FAS ‘has_disease_driver’ alcohol)