Fig. 6
Source data are provided as a Source Data file
FLI1 induces radioresistance in the NPC xenograft mouse model. A–B Assessment of FLI1 levels on radiotherapy efficacy in NPC xenografts. FLI1-overexpressing (FLI1) and empty vector (VEC)-transfected CNE1 cells A or FLI1-knockdown (shFLI1) and negative control (NC) 5-8F cells B were implanted into BALB/c nude mice, which were exposed to IR or not. Tumor volume and weight of the excised tumors were measured (left, excised tumors; middle, tumor volume; right, tumor weight). C–D Representative images of IHC staining and IHC scores for FLI1, TIE1 and cleaved caspase-3 in the excised tumors. Scale bars = 100 μm. **p < 0.01, ****p < 0.0001; ns not significant (Student’s t-test).