Fig. 7
From: P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization
P2RX7 promoted proliferation, migration and invasion of osteosarcoma cells via c-Myc in vitro. a, e Osteosarcoma cells were transfected with empty vector (P2RX7 EV), P2RX7 plasmid (P2RX7 OE), EV plus MYC shRNA (P2RX7 EV + shMYC) and OE plus shMYC (P2RX7 OE + shMYC), respectively. P2RX7-mediated promotion of cell proliferation was attenuated by c-Myc knockdown in osteosarcoma cells. b, f P2RX7-mediated acceleration of cell migration was suppressed by c-Myc knockdown in osteosarcoma cells. c, g c-Myc knockdown impaired P2RX7-induced invasiveness of osteosarcoma cells. d, h c-Myc knockdown reduced the ability of P2RX7 to promote cell cycle transition of osteosarcoma cells. Data are shown as mean ± standard deviation (SD). *p < 0.05, **p < 0.01, ***p < 0.001 versus corresponding P2RX7 EV or OE group